The a-current modulates learning via NMDA receptors containing the NR2B subunit

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Abstract

Synaptic plasticity involves short- and long-term events, although the molecular mechanisms that underlie these processes are not fully understood. The transient A-type K + current (I A) controls the excitability of the dendrites from CA1 pyramidal neurons by regulating the back-propagation of action potentials and shaping synaptic input. Here, we have studied how decreases in I A affect cognitive processes and synaptic plasticity. Using wild-type mice treated with 4-AP, an I A inhibitor, and mice lacking the DREAM protein, a transcriptional repressor and modulator of the I A, we demonstrate that impairment of I A decreases the stimulation threshold for learning and the induction of early-LTP. Hippocampal electrical recordings in both models revealed alterations in basal electrical oscillatory properties toward low-theta frequencies. In addition, we demonstrated that the facilitated learning induced by decreased I A requires the activation of NMDA receptors containing the NR2B subunit. Together, these findings point to a balance between the I A and the activity of NR2B-containing NMDA receptors in the regulation of learning. © 2011 Fontán-Lozano et al.

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Fontán-Lozano, Á., Suárez-Pereira, I., González-Forero, D., & Carrión, Á. M. (2011). The a-current modulates learning via NMDA receptors containing the NR2B subunit. PLoS ONE, 6(9). https://doi.org/10.1371/journal.pone.0024915

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