Nitric oxide synthesis inhibitor prevents vasodilation by insulin-like growth factor I

Abstract

The effect of insulin-like growth factor 1 (IGF-I) on renal blood flow was measured in the anaesthetized rat using an electromagnetic flow probe. Renal vasodilation induced by IGF-I (50 figlig) was completely inhibited by NG-nitro-1-arginine methyl ester (50 mg/kg), an inhibitor of nitric oxide biosynthesis, but only partially reduced by indomethacin (10 mg/kg). The involvement of nitric oxide synthesis in the renal actions of IGF-I is proposed.