Determining Ischaemic Thresholds Through Our Understanding of Cellular Metabolism

Abstract

Synopsis of clinical issues associated with the complexity of compartment syndromes and current diagnostic limitations. Comprehending the metabolic capacity of active skeletal muscle and its constant need for energy. Understanding the principle of an ischemic threshold and the localised techniques that are employed by muscle to counteract progressive ischaemia. Investigating the potential for tissue concentrations of key biochemical molecules involved in aerobic and anaerobic respiration to become markers of ischaemia. Investigating the role of direct tissue pH monitoring to become a future objective measure of muscle metabolic status related to ischaemia irrespective of the cause.