Analysis of trace amounts of drugs of abuse is important in a variety of situations, including forensic casework. Here, a method for the facile, rapid collection of traces of drugs from a variety of porous and nonporous surfaces, including fabrics, is detailed. A small amount of extraction solvent, including an internal standard, is applied to the fabric surface, followed by application of a patterned absorbent disk which resorbs much of the extraction solvent along with dissolved traces of any drug present. Over half of the extraction solvent is recovered in 15 s from many natural and synthetic fabrics, with weights ranging from 64 to 374 mg/in. 2 , by pressing a half-inch diameter patterned glass fiber membrane disk to the wetted area. The patterned disk is then placed in a standard OpenSpot™ holder of a direct analysis in real time (DART) mass spectrometer with a data collection time of 1 or 2 min. Semi-quantitation of low microgram levels of drugs is achieved by comparison of spectra to those from a standard control disk.
CITATION STYLE
Cunningham, D. D. (2018). Analysis of Trace Drugs of Abuse by Direct Analysis in Real Time (DART) Mass Spectrometry. In Methods in Molecular Biology (Vol. 1810, pp. 193–205). Humana Press Inc. https://doi.org/10.1007/978-1-4939-8579-1_17
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