ST3Gal-IV is a member of the β-galactoside α-2,3-sialyltransferase family, transferring sialic acid in α2,3 linkage from CMP-NeuAc preferentially to Galβ1-4GlcNAc termini, but also to Galβ1-3GlcNAc and Galβ1-3GalNAc termini on glycoproteins and glycolipids. Included among its acceptors is Lex (Galβ1-4(Fucα1-3)GlcNAc) to produce sialyl Lex, a glycan determinant important in leukocyte trafficking.
CITATION STYLE
Schnaar, R. L. (2014). ST3 beta-galactoside alpha-2,3-sialyltransferase 4 (ST3GAL4). In Handbook of Glycosyltransferases and Related Genes, Second Edition (Vol. 2, pp. 667–674). Springer Japan. https://doi.org/10.1007/978-4-431-54240-7_75
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