We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat- but also in dog-allergic patients.
CITATION STYLE
Apostolovic, D., Sánchez-Vidaurre, S., Waden, K., Curin, M., Grundström, J., Gafvelin, G., … van Hage, M. (2016). The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1. Allergy: European Journal of Allergy and Clinical Immunology, 71(10), 1490–1495. https://doi.org/10.1111/all.12955
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