Dynamics of FSH-induced follicular growth in subfertile women: Relationship with age, insulin resistance, oocyte yield and anti-Mullerian hormone

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Abstract

Background: During excess FSH treatment, different categories of follicles can be discerned: those responding and appearing to grow immediately (FolsS8) and those appearing subsequently during the follicular phase (Fols/d). These follicular categories were explored in cycles of assisted reproduction in the context of follicular biology, including primordial follicle pool (PFP) depletion, age, insulin resistance and potential markers. Methods: Follicular cohorts were examined in 365 conventional ART cycles and related to patient insulin sensitivity, plasma FSH and anti-Mullerian hormone (AMH). Results: Age had no influence upon the FolsS8 category but was associated with a significant (P < 0.005) decline in the Fols/d. In contrast, insulin-resistant polycystic ovary syndrome (IR-PCOS) showed a significant (P = 0.005) increase in FolsS8. Circulating AMH correlated strongly with oocyte yield and Fols/d. Conclusion: Age showed little impact on the initial follicular cohort, but a significant impact upon the secondary cohort, while insulin resistance appeared to promote the former category alone. The disturbance to follicular dynamics and AMH in IR-PCOS reflected a larger stockpile of FSH-sensitive follicles. Circulating AMH appears to represent all categories of antral follicles observed. © 2006 Oxford University Press.

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Fleming, R., Deshpande, N., Traynor, I., & Yates, R. W. S. (2006). Dynamics of FSH-induced follicular growth in subfertile women: Relationship with age, insulin resistance, oocyte yield and anti-Mullerian hormone. Human Reproduction, 21(6), 1436–1441. https://doi.org/10.1093/humrep/dei499

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