FoxO proteins and cardiac pathology

Abstract

The FoxO family of transcription factorsmediate a wide rangeof cellularresponses from celldeath to cellsurvival,growthinhibition and glucose utilization.Thiscomplex arrayof responses isregulatedbyanequallycomplex regulatorysystem, involvingphosphorylation, ubiquitinization and acetylation, in addition to interactionswith other transcription factorsand transcriptionalmodifiers. In heart,FoxOproteinshavebeenshownto beinvolved in development, in limitinghypertrophicgrowthresponses and in cardioprotectionprovidedbysilentinformation regulator 1 (Sirtl) However, the rangeof responses mediatedbyFoxOproteinsand the clearevidence for involvement ofFoxO regulatorsin cardiacpathology, suggest that further pathological actionsofFoxO family membersremainto be elucidated. © 2009 Landes Bioscience and Springer Science+Business Media.