We focus on actin cables in yeast as a model system for understanding cytoskeletal organization and the workings of actin itself. In particular, we highlight quantitative approaches on the kinetics of actin-cable assembly and methods of measuring their morphology by image analysis. Actin cables described by these studies can span greater lengths than a thousand end-to-end actin-monomers. Because of this difference in length scales, control of the actin-cable system constitutes a junction between short-range interactions - among actin-monomers and nucleating, polymerization-facilitating, side-binding, severing, and cross-linking proteins - and the emergence of cell-scale physical form as embodied by the actin cables themselves. © 2012 Springer Science+Business Media, LLC.
CITATION STYLE
Drake, T., Yusuf, E., & Vavylonis, D. (2012). A systems-biology approach to yeast actin cables. Advances in Experimental Medicine and Biology, 736, 325–335. https://doi.org/10.1007/978-1-4419-7210-1_19
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