Among the 62 patients in the double-blind portion of the study, 31 received aspirin pretreatment and showed inhibited platelet aggregation. Four of these patients (13 per cent) sustained post-cannulation radial-artery occlusion. Among the other 31 patients who received placebo and had normal platelet aggregation, 12 (39 per cent) experienced arterial occlusion (P<0.05 versus aspirin-treated group). The mean thrombus scores assigned after arteriography were 1.3 ± .2 SE in the aspirin-treated group and 1.9 ± .3 SE in the placebo group (P<0.05). An unexpected finding was that women appeared to benefit more from aspirin pretreatment than did the men. Among all women in the study the incidence of arterial occlusion was 63 per cent (12 of 19) for those who did not receive aspirin, compared with 27 per cent (7 of 26) for men in the control group. This discrepancy is probably related to the smaller size of women's arteries (2.0 mm ± 0.1 SEM versus 2.3 mm ± 0.1 SEM, P < 0.05).
CITATION STYLE
Bedford, R. F., & Ashford, T. P. (1979). Aspirin pretreatment prevents post-cannulation radial-artery thrombosis. Anesthesiology, 51(2), 176–178. https://doi.org/10.1097/00000542-197908000-00022
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