An overview of zinc and its importance in dermatology-Part II: The association of zinc with some dermatologic disorders

Abstract

In a study on humans and mice with Zn deficiency, Kawamura et al. revealed that allergic contact dermatitis was diminished, whereas irritant contact dermatitis was more severe and prolonged than that in controls. They also proved that epidermal Langerhans cells, which play a protective role against the ATP-mediated inflammatory signals, were decreased in number in humans and mice with the AE under the Zn-deficient diet [3].