It is now recognized that the cell-to-cell transmission of misfolded proteins such as α-synuclein contributes to the neurodegenerative phenotype in neurological disorders such as idiopathic Parkinson's disease, Dementia with Lewy bodies, and Parkinson's disease dementia. Thus, establishing cell-based models for the transmission of α-synuclein is of importance to understand the mechanisms of neurodegeneration in these disorders and to develop new therapies. Here we describe methods to study the neuron-to-neuron propagation of α-synuclein in an in vitro setting that also has in vivo applications. © 2012 Springer Science+Business Media, LLC.
CITATION STYLE
Lee, S. J., Desplats, P., Lee, H. J., Spencer, B., & Masliah, E. (2012). Cell-to-cell transmission of α-synuclein aggregates. Methods in Molecular Biology, 849, 347–359. https://doi.org/10.1007/978-1-61779-551-0_23
Mendeley helps you to discover research relevant for your work.