In recent years, the search for genetic determinants of type 2 diabetes has resulted in identification of numerous type 2 diabetes-associated loci as well as a number of loci associating with related prediabetic traits. These findings have illuminated new biological pathways contributing to the pathogenesis of type 2 diabetes, but have also demonstrated that type 2 diabetes is an extremely heterogeneous disease with limited overlap between genetic loci associating with type 2 diabetes and loci associating with diabetes-related traits, such as body mass index, fasting glucose levels, and fasting insulin levels. Combined, these loci only account for a fraction of the observed familial clustering of type 2 diabetes and only up to about 10 % of the variation in prediabetic quantitative traits. Improved methods are needed to dig deeper into a biological understanding of the pathophysiology of type 2 diabetes.
CITATION STYLE
Watanabe, R. M., & Hansen, T. (2016). Physiology insights. In The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation (pp. 207–221). Springer International Publishing. https://doi.org/10.1007/978-3-319-01574-3_9
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