Context and Objective: Insulin resistance and chronic inflammation are key elements in the pathogenesis of type 2 diabetes. We hypothesized that similar mechanisms could have a role in the development of diabetic retinopathy (DR), an important microvascular complication in Latinos with type 2 diabetes. Design and Setting: A cross-sectional, family-based, observational cohort study. Patients: Latino subjects with type 2 diabetes (n = 507), ascertained in families via a proband with known diabetes duration of 10 years or more and/or with DR, were included. Main Outcome Measures: Serum adiponectin was measured and insulin sensitivity was estimated using homeostasis model assessment of insulin resistance (HOMA-IR). DR was assessed by sevenfield digital fundus photography and graded using the modified Airlie House classification and the Early Treatment Diabetic Retinopathy Scale (range of severity levels, 10-85). Results: Fasting adiponectin concentrations were elevated in patients with DR compared to those without (12.9 ± 0.5 vs 10.5 ± 0.5 μg/mL; P = .0004) and remained significant after adjusting for multiple covariates (age, gender, body mass index, glycosylated hemoglobin, diabetes duration, statin use, blood pressure, and renal function; P = .013 to .018). Adiponectin was also positively correlated with severity ofDRin patients with nonproliferativeDR(P
Mendeley helps you to discover research relevant for your work.
CITATION STYLE
Kuo, J. Z., Guo, X., Klein, R., Klein, B. E., Genter, P., Roll, K., … Ipp, E. (2015). Adiponectin, insulin sensitivity and diabetic retinopathy in latinos with type 2 diabetes. Journal of Clinical Endocrinology and Metabolism, 100(9), 3348–3355. https://doi.org/10.1210/jc.2015-1221