Tissue-based biomarkers of tumor-vascular interactions

Abstract

Studies have indicated that the prognosis of cancer patients might be improved by targeting the tumor-associated vascular system. There is, however, a lack of markers that can predict the clinical response to such antitumor therapy and thereby select patients for optimal management. Whereas microvessel density is known to be an effective prognostic factor, information on response prediction is virtually lacking. In addition to the use of novel endothelial proteins for improved tumor imaging and targeting strategies, the potential practical value of selected histologic markers such as vascular density, microvessel proliferation, and vascular maturation for predictive purposes needs to be validated in future clinical studies.