Decline in T-cell generation leading to T-cell receptor repertoire contraction is a cornerstone of immune system aging, and consequent disorders. High-throughput sequencing enables in-depth immune repertoire characterization, but blood samples are too small to capture its total diversity. New computational models could enable accurate estimation of this diversity.
CITATION STYLE
Goronzy, J. J., Qi, Q., Olshen, R. A., & Weyand, C. M. (2015, November 19). High-throughput sequencing insights into T-cell receptor repertoire diversity in aging. Genome Medicine. BioMed Central Ltd. https://doi.org/10.1186/s13073-015-0242-3
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