Prunus armeniaca Leave Extract Protects against Isoniazid and Rifampicin Induced Nephrotoxicity through Modulation of Oxidative stress and Inflammation

Abstract

Nephropathy is a microvascular complication of anti-tuberculosis therapy that can disturb treatment and cause permanent kidney damage.The current study was de- signed to evaluate the possible protective effects of Prunus armeniaca leaves extract against isoniazid (INH) and rifampicin (RIF)-induced nephrotoxicity in rats. The ex- perimental rats received INH and RIF at dose level of 50 mg/kg, and either 100 mg or 200 mg/kg body weight Prunus armeniaca leaves extract orally for 45 days. INH/ RIF administration induced nephrotoxicity evidenced by the histopathological al- terations as well as significant (P<0.001) increase in serum urea, creatinine and uric acid. INH/RIF-intoxicated rats exhibited a significant increase in serum tumor ne- crosis factor alpha (P<0.01) and renal lipid peroxidation levels (P<0.001). Converse- ly, reduced glutathione content, and activity of superoxide dismutase and glutathione peroxidase were significantly declined in kidney of INH/RIF-induced rats. Concomi- tant supplementation with either dose of Prunus armeniaca leaves extract prevented the INH/RIF-induced biochemical and histopathological alterations. In conclusion, the present study confers new information on the protective effect of Prunus armeni- aca leaves extract against anti-tuberculosis therapy-induced nephrotoxicity. Prunus armeniaca protect against INH/RIF-induced renal injury through abolishment of in- flammation and oxidative stress, and potentiation of the antioxidant defense system. Keywords: