Carbonate hydroxyapatite functionalization: A comparative study towards (bio)molecules fixation

Abstract

Different methods for the functionalization of carbonate hydroxyapatite granules with free amine groups by reaction with (3-aminopropyl)triethoxysilane (APTES) have been compared in order to improve the potential for tethering of bioactive molecules to bioceramics. The combined use of tetraethoxyorthosilicate and APTES with acid catalysis resulted in an evident increase in amine surface grafting. © 2013 The Author(s) Published by the Royal Society. All rights reserved.