We demonstrate that loss-of-function yeast phenotypes are predictable by guilt-by-association in functional gene networks. Testing 1,102 loss-of-function phenotypes from genome-wide assays of yeast reveals predictability of diverse phenotypes, spanning cellular morphology, growth, metabolism, and quantitative cell shape features. We apply the method to extend a genome-wide screen by predicting, then verifying, genes whose disruption elongates yeast cells, and to predict human disease genes. To facilitate network-guided screens, a web server is available http://www.yeastnet.org. © 2007 McGary et al.; licensee BioMed Central Ltd.
CITATION STYLE
McGary, K. L., Lee, I., & Marcotte, E. M. (2007). Broad network-based predictability of Saccharomyces cerevisiae gene loss-of-function phenotypes. Genome Biology, 8(12). https://doi.org/10.1186/gb-2007-8-12-r258
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