Abstract
We studied the model of cerebral angiogenesis in vitro using lactate-releasing gelatin bioscaffolds and primary culture of brain endothelial cells. We found that development of microvessels from actively proliferating rat brain microvessels endothelial cells was greatly modified by the presence of lactate at the surface of the scaffold with different lactate-releasing ability. Fractal dimension of newly-established vessel loops allows precise characterizing the local microenvironment supporting cell growth on various types of gelatin scaffolds.
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Salmin, V., Morgun, A., Khilazheva, E., Pisareva, N., Boitsova, E., Lavrentiev, P., … Salmina, A. (2017). Secret life of tiny blood vessels: Lactate, scaffold and beyond. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 10208 LNCS, pp. 591–601). Springer Verlag. https://doi.org/10.1007/978-3-319-56148-6_53
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