Association of interleukin-10-592a>c and-819t>c polymorphisms with gastric cancer risk: A systematic review and meta-analysis of 44 case-control studies

Abstract

Introduction: A series of studies have evaluated the association between-592A>C and-819T>C polymorphisms in the promoter regions of Interleukin-10 (IL-10) and gastric cancer (GC) risk. However, the results remain inconclusive. Objective: To better understand the association of the polymorphisms with GC risk, we performed a comprehensive meta-analysis. Method: An electronic search was performed of several databases to identify relevant studies up to April 2018. Results: A total of 44 case-control studies, including 26 studies on IL-10-592A>C (5,332 cases and 8,272 controls) and 18 studies on IL-10-819T>C (3,431 cases and 6,109 controls) were selected. Overall,-592A>C polymorphism was associated with the risk of GC under the heterozygote model (OR=1.153, 95% CI=1.020-1.305, p=0.023), but not-819T>C polymorphism. When stratified by ethnicity, significant association was only observed in the Asians under the allele model (OR=1.153, 95% CI=1.007-1.320, p=0.040) and the heterozygote model (OR=1.218, 95% CI=1.076-1.379, p=0.002) for-592A>C. Conclusion: The current meta-analysis results inconsistent with previous meta-analyses; showed that the IL-10-592A>C polymorphism, but not-819T>C polymorphism, may be contributed to the susceptibility of GC in overall and Asian populations.