The effect of exogenous 3’ : 5’-adenosine monophosphate on urinary output in children with vasopressin-resistant diabetes insipidus

Abstract

3’:5’-Adenosine monophosphate (c-AMP) and dibutyryl 3’:5’- adenosine monophosphate (DB c-AMP) were given intravenously to six children with nephrogenic diabetes insipidus. Both nucleotides were unable to reduce, in a constant and reproducible manner, urine volume and free water clearance. Paradoxically, DB c-AMP, given as an infusion, caused a clear-cut rise in urine volume (an increase of 138.0—188.5%, mean of 172.8%, as compared with the preceding periods) without influencing creatinine excretion. © 1975 International Pediatric Research Foundation, Inc.