Immune cytokine response in combat casualties: Blast or explosive trauma with or without secondary sepsis

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Abstract

The aim of this study was to assess the prognostic value of tumor necrosis factor (TNF) α, interleukin (IL)-8, IL-4, and IL-10 in combat casualties. Fifty-six casualties with severe trauma (blast and explosive) who developed sepsis and 20 casualties with the same severity of trauma without sepsis were enrolled in this study. Fifty-five casualties developed multiple organ dysfunction syndrome; 36 died. Blood was drawn on the first day of trauma. Concentrations of IL-8, TNF-α, IL-4, and IL-10 were determined in plasma using enzyme-linked immunosorbent assays. Mean values of IL-8 were 230-fold, IL-10 were 42-fold, and TNF-α were 17-fold higher in trauma and sepsis group (p < 0.01). Mean values of IL-8 were 60-fold, TNF-α were 43.5-fold, and IL-10 were 70-fold higher in the multiple organ dysfunction syndrome group (p < 0.01). Mean values of IL-8 were 2.3-fold and IL-10 were 1.4-fold higher in nonsurvivors and TNF-α were 2.2-fold higher in survivors (p < 0.01). IL-4 had no significance as a predictor of severity and outcome.

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Surbatovic, M., Filipovic, N., Army, S., Radakovic, S., Stankovic, N., & Slavkovic, Z. (2007). Immune cytokine response in combat casualties: Blast or explosive trauma with or without secondary sepsis. Military Medicine, 172(2), 190–195. https://doi.org/10.7205/MILMED.172.2.190

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