Bacterium-like particles for efficient immune stimulation of existing vaccines and new subunit vaccines in mucosal applications

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Abstract

The successful development of a mucosal vaccine depends critically on the use of a safe and effective immunostimulant and/or carrier system. This review describes the effectiveness and mode of action of an immunostimulating particle, derived from bacteria, used in mucosal subunit vaccines. The non-living particles, designated bacterium-like particles are based on the food-grade bacterium Lactococcus lactis. The focus of the overview is on the development of intranasal BLP-based vaccines to prevent diseases caused by influenza and respiratory syncytial virus, and includes a selection of Phase I clinical data for the intranasal FluGEM vaccine. © 2013 Van Braeckel-Budimir, Haijema and Leenhouts.

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Van Braeckel-Budimir, N. V., Haijema, B. J., & Leenhouts, K. (2013). Bacterium-like particles for efficient immune stimulation of existing vaccines and new subunit vaccines in mucosal applications. Frontiers in Immunology, 4(SEP). https://doi.org/10.3389/fimmu.2013.00282

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