Sustained-input switches for transcription factors and microRNAs are central building blocks of eukaryotic gene circuits

14Citations
Citations of this article
56Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

WaRSwap is a randomization algorithm that for the first time provides a practical network motif discovery method for large multi-layer networks, for example those that include transcription factors, microRNAs, and non-regulatory protein coding genes. The algorithm is applicable to systems with tens of thousands of genes, while accounting for critical aspects of biological networks, including self-loops, large hubs, and target rearrangements. We validate WaRSwap on a newly inferred regulatory network from Arabidopsis thaliana, and compare outcomes on published Drosophila and human networks. Specifically, sustained input switches are among the few over-represented circuits across this diverse set of eukaryotes. © 2013 Megraw et al.; licensee BioMed Central Ltd.

Cite

CITATION STYLE

APA

Megraw, M., Mukherjee, S., & Ohler, U. (2013). Sustained-input switches for transcription factors and microRNAs are central building blocks of eukaryotic gene circuits. Genome Biology, 14(8). https://doi.org/10.1186/gb-2013-14-8-r85

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free