Pallak plot processing [2, 3] of Gd-shifted Ti relaxation-time images from a rat model of hemorrhagic transformation yielded estimates and maps of the blood-to-brain influx rate constant of Gd-DTPA (Ki). The Patlak plots also produced a heretofore unrecognized parameter, the distribution space of the intravascular- Gd-shifted protons (Vp), an index of blood-to-tissue transfer of water. The Ki values for Gd-DTPA were very high for the regions of blood-brain barrier (BBB) opening and were similar to those of 14C-sucrose concurrently obtained by quantitative autoradiographic (QAR) analysis. In these same ROI's, Vp was five-fold greater than normal, which suggests that the permeability of the BBB to water was also increased. The 14C-sucrose space of distribution in the ischemic ROI's was around 8%, thus indicating a sizable interstitial space. The spatial resolving power of Gd-DTPA-δTi imaging was rather good, although no match for 14C-sucrose-QAR. This study shows that quantitative δTi-MRI estimates of regional blood-brain transfer constants of Gd-DTPA and water distribution are possible when Patlak plots are employed to process the data. This approach may be useful for tracking the time-course of BBB barrier function in both animals and humans. © Springer-Verlag 2003.
CITATION STYLE
Fenstermacher, J. D., Knight, R. A., Ewing, J. R., Nagaraja, T., Nagesh, V., Yee, J. S., & Arniego, P. A. (2003). Estimating blood-brain barrier opening in a rat model of hemorrhagic transformation with Patlak plots of Gd-DTPA contrast-enhanced MRI. Acta Neurochirurgica, Supplementum, (86), 35–37. https://doi.org/10.1007/978-3-7091-0651-8_7
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