The present chapter attempts a detailed yet comprehensive account of the exceedingly complex molecular events involved in heart development, including description of the main differentiation signaling pathways, transcription factors, enhancers and gene regulatory networks, with a special emphasis on applying this continuously enlarging body of modern scientific knowledge to the field of stem cell differentiation into cardiomyocytes for diagnostic and therapeutic applications. MicroRNAs are also emerging as an important area of discovery aiming to revolutionize current therapies in cardiology, therefore we describe their involvement in cardiogenesis, proliferation/apoptosis, angiogenesis, fibrosis and hypertrophy. After reviewing the architectural organization, ultrastructure details and functional compartments of cardiomyocytes derived from in vitro and in vivo studies, we focus on molecular mechanisms involved in cardiac hypertrophy and fibrosis, particularly on calcium signaling events triggering these excessive adaptive responses. Further, we stress the embryogenetic and molecular differences between the right and left ventricle, as well as their pathophysiology specificities and clinical consequences.
CITATION STYLE
Amuzescu, B., & Maniu, H. (2018). Molecular and cellular biology of the right heart. In Right Heart Pathology: From Mechanism to Management (pp. 57–89). Springer International Publishing. https://doi.org/10.1007/978-3-319-73764-5_3
Mendeley helps you to discover research relevant for your work.