The cellular and molecular mechanisms of hematopoiesis

Abstract

Hematopoiesis is a complex and dynamic process where mature blood cells of the myeloid and lymphoid lineages are produced from a common hematopoietic progenitor cell. In adult mammals, this process occurs within the bone marrow where hematopoietic progenitors integrate signals and cues from the microenvironment to activate gene expression programs that control lineage specification and maturation. In this chapter, we will review the cellular intrinsic and extrinsic factors that contribute to the regulation of hematopoiesis in the adult bone marrow.