Daytime variation in hepatitis C virus replication kinetics following liver transplant

  • Zhuang X
  • Lai A
  • McKeating J
  • et al.
N/ACitations
Citations of this article
5Readers
Mendeley users who have this article in their library.

Abstract

Background: There is a growing interest in the role of circadian regulated pathways in disease pathogenesis. Methods: In a cohort of hepatitis C virus (HCV) infected patients undergoing liver transplantation, we observed differences in early viral infection kinetics of the allograft that associated with the time of liver transplant. Results: A higher frequency of subjects transplanted in the morning showed a rebound in viral RNA levels (n=4/6) during the first week post-surgery. In contrast, no viral rebound was observed in seven subjects transplanted in the afternoon. None of the other parameters previously reported to influence viral replication in the post-transplant setting, such as donor age, cold-ischemia time and length of surgery associated with viral rebound. Conclusions: These observation highlights a role for circadian processes to regulate HCV infection of the liver and warrants further investigation.

Cite

CITATION STYLE

APA

Zhuang, X., Lai, A. G., McKeating, J. A., Rowe, I., & Balfe, P. (2018). Daytime variation in hepatitis C virus replication kinetics following liver transplant. Wellcome Open Research, 3, 96. https://doi.org/10.12688/wellcomeopenres.14696.1

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free