Background: There is a growing interest in the role of circadian regulated pathways in disease pathogenesis. Methods: In a cohort of hepatitis C virus (HCV) infected patients undergoing liver transplantation, we observed differences in early viral infection kinetics of the allograft that associated with the time of liver transplant. Results: A higher frequency of subjects transplanted in the morning showed a rebound in viral RNA levels (n=4/6) during the first week post-surgery. In contrast, no viral rebound was observed in seven subjects transplanted in the afternoon. None of the other parameters previously reported to influence viral replication in the post-transplant setting, such as donor age, cold-ischemia time and length of surgery associated with viral rebound. Conclusions: These observation highlights a role for circadian processes to regulate HCV infection of the liver and warrants further investigation.
CITATION STYLE
Zhuang, X., Lai, A. G., McKeating, J. A., Rowe, I., & Balfe, P. (2018). Daytime variation in hepatitis C virus replication kinetics following liver transplant. Wellcome Open Research, 3, 96. https://doi.org/10.12688/wellcomeopenres.14696.1
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