Cisplatin is a commonly used chemotherapeutic agent that has a major limitation because of its nephrotoxicity. Taurine is an important osmolyte that has been found to protect against cisplatin-induced apoptosis in renal cells in vitro. To determine whether over-expression of hTauT protects against cisplatin-induced acute kidney injury (AKI) in vivo, animals (wt and transgenic) were injected with cisplatin and the levels of BUN and serum creatinine were measured. Saline-injected mice were used as a control. The results showed that the levels of BUN and creatinine were significantly increased in the cisplatin-injected wild-type mice (110 ± 12 mg/dl and 0.98 ± 0.05 mg/dl) as compared to the saline-injected wild type mice (20 ± 2.5 mg/dl and 0.52 ± 0.06 mg/dl). However, over-expression of hTauT effectively prevented the progression of cisplatin-induced AKI in hTauT transgenic mice, as measured by the levels of BUN and serum creatininelevels (23 ± 3.5 mg/dl and 0.6 ± 0.05 mg/dl). © 2009 Springer Science+Business Media, LLC.
CITATION STYLE
Han, X., & Chesney, R. W. (2009). TauT protects against cisplatin-induced acute kidney injury (AKI) established in a TauT transgenic mice model. In Advances in Experimental Medicine and Biology (Vol. 643, pp. 113–122). https://doi.org/10.1007/978-0-387-75681-3_12
Mendeley helps you to discover research relevant for your work.