Temporal excitation patterns on the cerebral cortex as a result of migraine modeling

Abstract

The complex, highly individual, geometry of the cerebral cortex in humans presents a major challenge in studying the spreading of spontaneous neuronal activity. Recent computational advances [1] allow to simulate the propagation of depolarization waves on the macroscale and for individual geometries, reconstructed from accurate medical imaging as MRI, with high levels of detail. In this paper we take advantage of such technique to study the temporal excitation patterns that follow the passage of a depolarization wave on the cerebral cortex.