Activities of Z-ajoene against tumour and viral spreading in vitro

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Abstract

Z-ajoene is a garlic-derived compound with known anti-tumour properties. This report argues in favour of pro-apoptotic and cell cycle blockage activities of Z-ajoene on various cell lines involving activation of the p53-family gene products, p53, p63 and p73, at indicated doses. According to its known anti-proteasome activity, Z-ajoene induced a downregulation of MHC-class I expression at the surface of treated cells but did not impair their recognition by CD8+ T cells. We further demonstrated a new activity of Z-ajoene against human cytomegalovirus spreading in vitro that was mediated by an increased number of apoptotic cells after infection. Altogether our data point at the ubiquitous efficiency of Z-ajoene as a new compound to fight against cancers of various origins including those that put up viruses. © 2007 INSERM.

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Terrasson, J., Xu, B., Li, M., Allart, S., Davignon, J. L., Zhang, L. H., … Davrinche, C. (2007). Activities of Z-ajoene against tumour and viral spreading in vitro. Fundamental and Clinical Pharmacology, 21(3), 281–289. https://doi.org/10.1111/j.1472-8206.2007.00470.x

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