The Mongolian gerbil is an efficient, robust, and cost-effective rodent model that recapitulates many features of H. pylori-induced gastric inflammation and carcinogenesis in humans, allowing for targeted investigation of the bacterial determinants and environmental factors and, to a lesser degree, host constituents that govern H. pylori-mediated disease. This chapter discusses means through which the Mongolian gerbil model has been used to define mechanisms of H. pylori-inflammation and cancer as well as the current materials and methods for utilizing this model of microbially induced disease.
CITATION STYLE
Noto, J. M., Romero-Gallo, J., Blanca Piazuelo, M., & Peek, R. M. (2016). The Mongolian gerbil: A robust model of helicobacter pylori-induced gastric inflammation and cancer. Methods in Molecular Biology, 1422, 263–280. https://doi.org/10.1007/978-1-4939-3603-8_24
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