Restless legs syndrome was the first isolated clinical manifestation in four siblings of a family with familial amyloid polyneuropathy. Clinical and electrophysiological evidence of peripheral neuropathy appeared after a variable time interval. Polysomnography showed abnormal sleep patterns and nocturnal myoclonus in all patients. The restless legs syndrome responded favourably to clonazepam.
CITATION STYLE
Salvi, F., Montagna, P., Plasmati, R., Rubboli, G., Cirignotta, F., Veilleux, M., … Tassinari, C. A. (1990). Restless legs syndrome and nocturnal myoclonus: Initial clinical manifestation of familial amyloid polyneuropathy. Journal of Neurology Neurosurgery and Psychiatry, 53(6), 522–525. https://doi.org/10.1136/jnnp.53.6.522
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