Restless legs syndrome and nocturnal myoclonus: Initial clinical manifestation of familial amyloid polyneuropathy

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Abstract

Restless legs syndrome was the first isolated clinical manifestation in four siblings of a family with familial amyloid polyneuropathy. Clinical and electrophysiological evidence of peripheral neuropathy appeared after a variable time interval. Polysomnography showed abnormal sleep patterns and nocturnal myoclonus in all patients. The restless legs syndrome responded favourably to clonazepam.

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APA

Salvi, F., Montagna, P., Plasmati, R., Rubboli, G., Cirignotta, F., Veilleux, M., … Tassinari, C. A. (1990). Restless legs syndrome and nocturnal myoclonus: Initial clinical manifestation of familial amyloid polyneuropathy. Journal of Neurology Neurosurgery and Psychiatry, 53(6), 522–525. https://doi.org/10.1136/jnnp.53.6.522

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