Ca2+ influx by plasma membrane Ca2+ channels is the crucial component of the receptor-evoked Ca2+ signal. The two main Ca2+ influx channels of non-excitable cells are the Orai and TRPC families of Ca2+ channels. These channels are activated in response to cell stimulation and Ca2+ release from the endoplasmic reticulum (ER). The protein that conveys the Ca2+ content of the ER to the plasma membrane is the ER Ca2+ sensor STIM1. STIM1 activates the Orai channels and is obligatory for channel opening. TRPC channels can function in two modes, as STIM1-dependent and STIM1-independent. When activated by STIM1, both channel types function at the ER/PM (plasma membrane) junctions. This chapter describes the properties and regulation of the channels by STIM1, with emphasis how and when TRPC channels function as STIM1-dependent and STIM1-independent modes and their unique Ca2+-dependent physiological functions that are not shared with the Orai channels.
CITATION STYLE
Bodnar, D., Chung, W. Y., Yang, D., Hong, J. H., Jha, A., & Muallem, S. (2017). STIM-TRP pathways and microdomain organization: Ca2+ influx channels: The orai-STIM1-TRPC complexes. In Advances in Experimental Medicine and Biology (Vol. 993, pp. 139–157). Springer New York LLC. https://doi.org/10.1007/978-3-319-57732-6_8
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