L-Arginine in Clinical Nutrition

Abstract

Includes index. Preface; Series Editor Page; Part I: Basic Processes at the Cellular Level; Part II: l-Arginine Metabolism and Functions; Part III: l-Arginine Status in Cells Related to Organ Damage and Disease; Part IV: l-Arginine Status and Use in Healthy Individuals; Part V: l-Arginine and Diseases of the Gastrointestinal Tract (GI Tract); Part VI: Therapeutic Uses of l-Arginine: Diabetes, Obesity, and Cardiovascular Diseases; Part VII: Therapeutic Uses of l-Arginine: Cancer, Sickle Cell Disease, Wound Healing, and Infectious Disease; About the Series Editor; Editor Biography; Contents; Contents Part I: Basic Processes at the Cellular LevelsChapter 1: l-Arginine Uptake by Cells; Introduction; Cationic Amino Acid Transport; Measurement of l-Arginine Uptake; Non-linear Modelling of Uptake; Validation of a Non-linear Method Determining l-Arginine Uptake; Effect of Salt and Inhibitors on l-Arginine Uptake; Kinetics of l-Arginine Transport and the l-Arginine Paradox; Conclusions; References; Chapter 2: l-Arginine and the Expression of HSP70 and p53 Proteins; Introduction; Heat Shock Proteins; Programmed Cell Death, p53 and Caspase 3; Previous Studies on l-Arginine ConclusionsReferences; Chapter 3: AMP-Activated Protein Kinase and l-Arginine; Introduction; Intracellular ARG Does Not Determine NO Production; Dualistic Nature of NOS; Role of Oxidative Stress During ARG Continuous Supplementation; Role of NOS Cofactor (BH4) in Tolerance; Role of AMP-Activated Protein Kinase (AMPK) Towards ARG Responses; Conclusion; References; Chapter 4: Amidine-Based Compounds Affecting l-Arginine Metabolism; Introduction; Amidine-Based Inhibitors of Nitric Oxide Synthase; Amidine-Based Inhibitors of Human DDAH1; Amidine-Based Inhibitors of PAD L-Arginine-Based Inhibitors of PRMT1 Conclusions; References; Chapter 5: Oxy- and Sulfoanalogues of l-Arginine; Introduction; Biological Role of Canavanine, a Natural Oxy-l-arginine Analogue; Synthesis and Biological Effects of Synthetic Oxy- and Sulfoarginine Analogues; Conclusion; References; Chapter 6: Regulation of Expression and Activity of l-Arginine Transporters by Nutrients and Hormones: A Focus in Transcriptional Mechanisms Regulated by Glucose and Insulin; Introduction; l-Arginine Transporters and Endothelial Function; Transcriptional Regulation of CAT-1 Regulation of SLC7A1 by Insulin Regulation of SLC7A1 by d-glucose; Conclusions; References; Chapter 7: l-Arginine, Pancreatic Beta Cell Function, and Diabetes: Mechanisms of…