Background: Streptococcus pyogenes (group A Streptococcus [GAS]) is a major human pathogen that causes a wide spectrum of clinical manifestations. Although invasive GAS (iGAS) infections are relatively uncommon, emm3/ST15 GAS is a highly virulent, invasive, and pathogenic strain. Global molecular epidemiology analysis has suggested that the frequency of emm3 GAS has been recently increasing. Case presentation: A 14-year-old patient was diagnosed with streptococcal toxic shock syndrome and severe pneumonia, impaired renal function, and rhabdomyolysis. GAS was isolated from a culture of endotracheal aspirates and designated as KS030. Comparative genome analysis suggested that KS030 is classified as emm3 (emm-type) and ST15 (multilocus sequencing typing [MLST]), which is similar to iGAS isolates identified in the UK (2013) and Switzerland (2015). Conclusions: We conclude that the global dissemination of emm3/ST15 GAS strain has the potential to cause invasive disease.
CITATION STYLE
Sekizuka, T., Nai, E., Yoshida, T., Endo, S., Hamajima, E., Akiyama, S., … Kuroda, M. (2017). Streptococcal toxic shock syndrome caused by the dissemination of an invasive emm3/ST15 strain of Streptococcus pyogenes. BMC Infectious Diseases, 17(1). https://doi.org/10.1186/s12879-017-2870-2
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