Neuropathological Findings in Experimentally Infected Guinea Pigs

Abstract

With 5 Figures We examined neuropathologically 15 guinea pigs infected with the Marburg-Virus. The animals were inoculated intra peritoneally and intracerebrally and became ill 7 to 12 days after injection. The duration of illness was 2-9 days (Table 1). There were no serious neurological findings. After preparation with formalin and Table 1. Nr. : Duration of illness Encephalitis Immunofluorescence intraperitoneal inoculation 129 8 days + 131 8 days + 132 7 days + + 133 8 days + 139 7 days + 67 9 days + not examined 68 8 days not examined 81 8 days + not examined 82 7 days not examined intracerebral inoculation 95 2 days 0 96 2/4 days + 0 97 3 days 0 114 5 days + (+) 115 6 days 0 116 7 days 0 embedding in paraffin, the brains were cut in series. About every 10th slice was colored with Cresylviolet or Haemalaun-Eosin. In negative cases we colored in closer sequence. Five out of 15 brains showed glial-nodule encephalitis; 2 of the animals were inoculated intracerebrally, 3 intraperitoneally. The glial nodules are sparse, in 2 cases even rare. They are found in the grey and white matter, but definitely more often in the grey matter.