Multiple myeloma with dural mater involvement

Abstract

Multiple myeloma is an incurable clonal B-cell malignancy which may present with neoplastic monoclonal plasma cells in either bone or soft tissues. Central nervous system (CNS) involvement such as dural myeloma or intraparenchymal infiltration, or with diffuse leptomeningeal involvement, is uncommon. Dural involvement of myeloma without parenchymal or leptomeningeal disease is an even rarer occurrence; therefore there are no established treatment guidelines for CNS myelomatosis. Here we reported a refractory MM patient progressed to dura mater involvement after the induction therapy but showed good response to lenalidomide treatment. Keywords: Multiple myeloma, dura mater involvement, lenalidomide This work was supported by grants 81670104 from the National Natural Science Foundation of China (NSFC). Disclosure The authors report no conflicts of interest in this work.