Acquired hemostatic disorders 7

Abstract

Acquired hemostatic disorders comprise thrombocytopenia and platelet dysfunction, coagulation factor deficiencies, excessive anticoagulation, and hemorrhagic complications due to antiplatelet drugs, anticoagulation, and thrombolysis. Blood disorders associated with myeloproliferative neoplasms and disseminated intravascular coagulation can cause both bleeding and thrombosis. Heparin-induced thrombocytopenia, antiphospholipid antibody syndrome, and thrombotic microangiopathies are conditions that can cause thrombocytopenia, but they are more frequently responsible for thrombosis than for bleeding. This chapter sets out diagnostic and management strategies for acquired hemostatic disorders, with a particular emphasis on features that can prove useful in a perioperative context. Antiplatelet and anticoagulant drug complications are presented in Chap. 8.