Dumb and dumber - The potential waste of a useful antistaphylococcal agent: Emerging fusidic acid resistance in Staphylococcus aureus

155Citations
Citations of this article
134Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Fusidic acid has activity against a range of pathogens but has mainly been used to treat staphylococcal infections, Fusidic acid monotherapy, especially topical preparations, has been strongly associated with the emergence of fusidic acid resistance among both methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible S. aureus. Key resistance determinants include mutations in the fusA gene, which encodes elongation factor G, and plasmid-mediated resistance (i.e., acquisition of resistance gene fusB). Clonal outbreaks of fusidic acid-resistant S. aureus have been noted throughout the United Kingdom and Europe, such that the efficacy of fusidic acid is threatened. Fusidic acid in combination with other agents, such as rifampicin, has proven effective for difficult-to-treat MRSA infections and provides a convenient oral alternative to oxazolidinones. Ensuring that systemic fusidic acid is always used in combination and that the use of topical fusidic acid is either abolished or restricted will be vital if we are to prevent the loss of this potentially useful agent. © 2005 by the Infectious Diseases Society of America. All rights reserved.

Cite

CITATION STYLE

APA

Howden, B. P., & Grayson, M. L. (2006, February 1). Dumb and dumber - The potential waste of a useful antistaphylococcal agent: Emerging fusidic acid resistance in Staphylococcus aureus. Clinical Infectious Diseases. https://doi.org/10.1086/499365

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free