UJI AKTIVITAS ANTIINFLAMASI EXSTRAK ETANOL RIMPANG ANDONG MERAH (Cordyline fruticosa (L.) A Chev) PADA UDEMA KAKI TIKUS WISTAR YANG DIINDUKSI KARAGENAN

Abstract

Rhizome of red andong (Cordyline fruticosa (L.) A. Chev) is a medicinal plant that contains saponins known to be anti-inflammatory. The research aimed to assess the anti-inflammatory activity of the rhizome ethanol extract of red andong. Phytochemical analysis was done qualitatively by using phytochemical reagents. Anti-inflammatory activity was evaluated using 25 Sprague Dawley male rats which had been divided into five groups: negative control (P1), positive control (P2), and group P3, P4, and P5 given extract at doses of 125; 250; and 500 mg/kgBW, respectively. A phytochemical study revealed that the rhizome ethanol extract consisted of alkaloids, steroids, phenolic, flavonoids and saponins compounds. The anti-inflammatory activity test showed that the administration of the extract at a dose of 125 mg/kgBW resulted in an inflammatory inhibition of using 65,876%, on the other hand, a dose of 250 mg/kgBW could inhibit inflammation by 59,994%, and a dose of 500 mg/kgBW had the inflammatory inhibition of 3,908% for 360 minutes of observation. The results of the probit analysis gave an ED50 value of 158,48 mg/kgBW. Keywords: anti-inflammatory activity, extract, rhizome, red andong.