Review: Hydrotropy as Prominent Approach for Enhancement of Aqueous Solubility of Drugs

Abstract

Solubility is crucial element to achieve the desired drug absorption in the total pharmacological response. Low water solubility can considerably limit the medication efficacy, and to improve aqueous solubility, a variety of approaches are employed. The capacity which increases water solubility for particular drug can thus be a useful tool for enhancing efficiency and/or decreasing negative effects. This is true for parental administered, topically applied and orally consumed solutions. It is a difficult work for researchers and pharmaceutical scientist to use solubility features in bioavailability, pharmacological effect and solubility enhancement of diverse weakly soluble substance. Hydrotropy is one of the strategies for increasing solubility. The purpose of this paper is to examine the hydrotropy Solubilization technique and to highlight the mechanism and different prospective of this method. Keywords: Hydrotropy, mechanism, formation of hydrotropes, Solubility