Andrographis paniculata extract relieves pain and inflammation in monosodium iodoacetate-induced osteoarthritis and acetic acid-inducedwrithing in animal models

7Citations
Citations of this article
14Readers
Mendeley users who have this article in their library.

Abstract

Osteoarthritis (OA), being the most prominent degenerative joint disease is affecting millions of elderly people worldwide. Although Andrographis paniculata is an ethnic medicine with a long history of being used as analgesic agent, no study using a monosodium iodoacetate (MIA) model has investigated its potential activities against OA. In this study, experimental OA was induced in rats with a knee injection of MIA, which represents the pathological characteristics of OA in humans. A. paniculata extract (APE) substantially reversed the loss of hind limb weight-bearing and the cartilage damage resulted from the OA induction in rats. Additionally, the levels of serum pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α as well as the concentration of matrix metalloproteinases, including MMP-1, MMP-3, MMP-8, and MMP-13 were decreased by APE administration. Acetic acid-induced writhing responses in mice which quantitatively measure pain were significantly reduced by APE. In vitro, APE inhibited the generation of NO and downregulated the expression of IL-1β, IL-6, COX-2, and iNOS in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. The above results suggest the potential use APE as a therapeutic agent against OA.

Cite

CITATION STYLE

APA

Lee, D., Baek, C. Y., Hwang, J. H., & Kim, M. Y. (2020). Andrographis paniculata extract relieves pain and inflammation in monosodium iodoacetate-induced osteoarthritis and acetic acid-inducedwrithing in animal models. Processes, 8(7). https://doi.org/10.3390/pr8070873

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free