Abstract
Dual system for proteins: The site-specific two-color labeling of a Rab GTPase was achieved in a one-pot procedure by combination of chemoselective native chemical ligation and oxime ligation. This strategy could be a general, facile, and efficient method for specific multiple modifications of a given protein. The Rab GTPase biosensor was demonstrated for protein folding and protein-protein interaction studies. © 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Yi, L., Sun, H., Itzen, A., Triola, G., Waldmann, H., Goody, R. S., & Wu, Y. W. (2011). One-pot dual-labeling of a protein by two chemoselective reactions. Angewandte Chemie - International Edition, 50(36), 8287–8290. https://doi.org/10.1002/anie.201100840
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