Effects of Jumping Exercise and Nutritional Management on Bone Mineral Density and Bone Turnover Markers in a Young Man

Abstract

Volume 1 • Issue 4 • 1000e105 absorptiometry with a Prodigy Advance (GE Healthcare, Madison, USA), which corresponding to 84% and 80% of the young adult mean (YAM). Blood and urine samples were obtained in the morning and were analyzed to assess biochemical markers; serum calcium, phosphorus, alkaline phosphatase (ALP), bone-specific ALP (BAP), undercarboxylated osteocalcin (ucOC), intact parathyroid hormone (iPTH), and urinary cross-linked N-terminal telopeptides of type I collagen (NTX). In particular, the serum levels of BAP, ucOC, and iPTH were measured by chemiluminescent enzyme immunoassay (CLEIA), electrochemiluminescent immunoassay (ECLIA), and ECLIA, respectively and the urinary level of NTX was measured by enzyme immunoassay (EIA). Although the serum level of ucOC was higher than the normal range, the serum or urinary levels of other biochemical markers were all within the normal ranges (Table 1). The patient was instructed to perform maximum jumping exercise (5 times per day, 5 days per week) and intake calcium (800 mg/day), vitamin D (800 IU or 20 µg/day), and vitamin K (300 μg/day) based on the recommended daily intake of calcium, vitamin D, and vitamin K [4]. Exercise and nutritional intakes were continued for 6 months, and the effect of this intervention was evaluated by measuring the BMD and biochemical markers. The patients complied with this intervention. The lumbar spine and femoral neck BMD increased by 2.9% and 4.7%, respectively (Figure 1). The serum levels of ALP, BAP, ucOC, and iPTH decreased (Table 1). No adverse events were observed. Abstract The strategy for increasing bone mineral density (BMD) has not been established in young men with low BMD. We report on a case of a young man with low BMD who was treated with exercise and nutritional management. A 29-year of old man consulted our clinic because of low BMD. He was instructed to perform maximum jumping exercise (5 times per day, 5 days per week) and intake calcium (800 mg/day), vitamin D (800 IU or 20 μg/day), and vitamin K (300 μg/day) for 6 months. The lumbar spine and femoral neck BMD increased by 2.9% and 4.7%, respectively. These results suggest the effectiveness of maximum jumping exercise and nutritional management (calcium, vitamin D, and vitamin K) on the BMD of the clinically relevant skeletal sites in young men with low BMD.