Chemokines (chemoattractant cytokines) induce potent and selective chemotaxis of leukocyte subsets in vitro. Here, we review briefly the chemokines shown to induce eosinophil chemotaxis in vitro and describe a novel model for the study of the ability of chemokines to stimulate eosinophil migration in vivo. Eosinophils were purified from the blood of mice over-expressing the IL-S gene and labelled with 111 In. Only the C-C chemokines, eotaxin and MIP- 1 α, but not RANTES, MCP-1, MCP-3, MCP-4, MIP-1β, KC and MIP-2, effectively induced the recruitment of 111 In-eosinophils in mouse skin. We suggest that this mouse model will be useful in assessing the role of endogenously-generated chemokines in mediating eosinophil migration to sites of allergic inflammation in vivo.
CITATION STYLE
Teixeira, M. M., Williams, T. J., & Hellewell, P. G. (1997). Description of an In Vivo Model for the Assessment of Eosinophil Chemoattractants in the Mouse. Memorias Do Instituto Oswaldo Cruz, 92 SUPPL. 2, 211–214. https://doi.org/10.1590/S0074-02761997000800029
Mendeley helps you to discover research relevant for your work.