Early T cell differentiated chronic myeloid leukemia blast crisis with rearrangement of the breakpoint cluster region but not of the T cell receptor β chain genes

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Abstract

Early T cell differentiation is described in a case of Philadelphia chromosome-positive chronic myeloid leukemia (CML) in blast crisis, supporting multi-lineage differentiation potential of CML precursor cells. In the absence of myeloid markers, strong positivity for terminal deoxynucleotidyl transferase (TdT) and reactivity with T cell antibody 3A1, but lack of more mature T cell antigens, provided evidence for immature T cell differentiation. Molecular analysis of the breakpoint cluster region (bcr) in chromosome 22 revealed a rearrangement and thus confirmed the CML origin of the early T cell blasts. T cell receptor β chain sequences were found in germline configuration and therefore suggest a very immature stage of T cell differentiation in the CML blasts.

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Gramatzki, M., Bartram, C. R., Müller, D., Walter, M., Tittelbach, H., & Kalden, J. R. (1987). Early T cell differentiated chronic myeloid leukemia blast crisis with rearrangement of the breakpoint cluster region but not of the T cell receptor β chain genes. Blood, 69(4), 1082–1086. https://doi.org/10.1182/blood.v69.4.1082.1082

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