OMICs studies and endometriosis biomarker identification

Abstract

The fast development and capabilities of high-throughput 'omics' technologies have provided new insights into the complexity of endometriosis and enabled the identification of novel diagnostic biomarkers. In this chapter, we take a closer look at high-throughput genomics, transcriptomics, epigenomics, proteomics, and metabolomics studies applied in endometriosis research. We summarise the existing information concerning 'omics' studies applied to blood, endometrium, endometriotic lesions, and body fluids in order to describe the potential disease-specific biomarkers. Also, we discuss the importance of sample collection, proper study design, data processing, and analysis in high-throughput studies. And finally, future perspectives in endometriosis biomarker research will be provided.