In vitro susceptibility testing of bedaquiline against Mycobacterium avium complex

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Abstract

We performed bedaquiline broth microdilution susceptibility testing using Clinical and Laboratory Standards Institute (CLSI) guidelines on 103 respiratory isolates of Mycobacterium avium complex (MAC), including multidrug-resistant isolates. Approximately 90% of isolates had bedaquiline MICs of ≤0.008 μg/ml, and 102/103 isolates had MICs of ≤0.015 μg/ml. Bedaquiline has excellent potential for use in patients with MAC infections, although for reasons of its metabolism by the cytochrome P450 system, it should not be given with rifampin.

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Brown-Elliott, B. A., Philley, J. V., Griffith, D. E., Thakkar, F., & Wallace, R. J. (2017). In vitro susceptibility testing of bedaquiline against Mycobacterium avium complex. Antimicrobial Agents and Chemotherapy, 61(2). https://doi.org/10.1128/AAC.01798-16

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